Why the study?
Does converting-enzyme inhibition reduce arterial pressure and total peripheral resistance in salt-deprived and renal hypertensive rats?
Population
Rats (chronically salt-deprived, renal hypertensive via renal artery constriction, and normotensive controls)
Comparison
Injection of converting-enzyme inhibitor vs Normotensive control animals and baseline…
Design
Preclinical
Authors
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Ang II inhibition markedly lowers pressure in salt-deprived but not renal hypertensive rats; leaves open other mechanisms in chronic models.
Does converting-enzyme inhibition reduce arterial pressure and total peripheral resistance in salt-deprived and renal hypertensive rats?
The study demonstrates that while angiotensin II is a major contributor to peripheral resistance in salt deprivation, it only partially accounts for the elevated resistance in chronic renal hypertension.
Coleman et al. (1974) studied this question.
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