Why the study?
Does converting enzyme inhibitor injection alter immediate hemodynamic response in mature Wistar rats fed a low-salt diet compared to normal rats?
Population
Mature Wistar rats fed a low-salt diet for 1 month, under pentobarbital anesthesia
Comparison
Converting enzyme inhibitor injection vs Normal rats (fed normal diet)
Design
Preclinical
Follow-up
immediate
Authors
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Angiotensin may support resistance in salt-deprived states; leaves open translation to human salt-sensitive hypertension.
Does converting enzyme inhibitor injection alter immediate hemodynamic response in mature Wistar rats fed a low-salt diet compared to normal rats?
In salt-deprived rats, circulatory function is maintained by angiotensin-supported total peripheral resistance and decreased venous compliance.
Coleman et al. (1975) studied this question.
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