Key result
Heart failure with preserved ejection fraction is associated with exaggerated neuromuscular fatigue during exercise, likely due to compromised peripheral hemodynamic responses.
Compromised peripheral hemodynamics in HFpEF accelerate exercise-induced neuromuscular fatigue, likely accounting for a significant portion of the exercise intolerance typical in this population.
May contribute to HFpEF exercise intolerance; hypothesis-generating for peripheral hemodynamic interventions.
The susceptibility to neuromuscular fatigue during exercise is substantially exaggerated in individuals with heart failure with a preserved ejection fraction. The faster rate of fatigue development is associated with the compromised peripheral hemodynamic response characterizing these patients during exercise. Given the role of neuromuscular fatigue as a factor limiting exercise, this impairment likely accounts for a significant portion of the exercise intolerance typical for this population.
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Weavil et al. (2020) conducted a review in Heart failure with preserved ejection fraction. Heart failure with preserved ejection fraction was evaluated on Neuromuscular fatigue during exercise. Heart failure with preserved ejection fraction is associated with exaggerated neuromuscular fatigue during exercise, likely due to compromised peripheral hemodynamic responses.
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