Deletion of the SL1 structure in the 3' noncoding region of FMDV RNA attenuates the virus in swine while preserving immunogenicity, supporting the potential of RNA-based vaccines for foot-and-mouth disease.
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May inform attenuated RNA vaccine design for FMD in swine; hypothesis-generating and requires validation before any application.
Rodríguez‐Pulido et al. (2009) studied this question.
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