What question did this study set out to answer?

To assess the frequency, magnitude, and clinical implications of liver biochemical test abnormalities in patients with dengue fever during an outbreak.

September 1, 1992American Journal of Tropical Medicine and Hygiene

Liver Biochemical Tests and Dengue Fever

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Authors

CKChung-Huang KuoChang Gung Memorial Hospital CCChi‐Sin ChangchienChang Gung University CLChi-Kin LanPingtung Christian Hospital

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Implication

Observational study reveals frequent transaminase elevation and hepatic injury in dengue fever patients, indicating that dengue should be evaluated in the differential diagnosis of acute hepatitis.

Key Points

To assess the frequency, magnitude, and clinical implications of liver biochemical test abnormalities in patients with dengue fever during an outbreak.
Evaluated liver biochemical markers in 270 patients (125 males and 145 females) diagnosed with dengue fever during an outbreak spanning November 1987 to December 1988.
Measured serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase (G-GT), and performed liver biopsies in two patients.
Abnormal biochemical levels were detected for AST in 93.3%, ALT in 82.2%, G-GT in 83.0%, alkaline phosphatase in 16.3%, and bilirubin in 7.2% of patients.
Enzyme increases were mostly mild to moderate, but AST and ALT exceeded 10-fold the upper limit of normal in 11.1% and 7.4% of patients, respectively; AST peaked at day 9 and normalized within two weeks.
Transaminase elevations did not differ by hepatitis B or C status but were significantly higher in patients with bleeding; liver biopsies showed lobular hepatitis, and 3 of 5 fatal cases died of hepatic failure.

Cite This Study

Kuo et al. (1992) studied this question.

synapsesocial.com/papers/6a7dccb81ec832c82ccdb099 https://doi.org/10.4269/ajtmh.1992.47.265

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Implication

Observational study reveals frequent transaminase elevation and hepatic injury in dengue fever patients, indicating that dengue should be evaluated in the differential diagnosis of acute hepatitis.

Liver Biochemical Tests and Dengue Fever

Discussion

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Implication

Key Points

Cite This Study

Liver Biochemical Tests and Dengue Fever

Discussion

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Implication

Key Points

Cite This Study

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