Why the study?
Does morbid obesity increase the risk of all-cause mortality or transplantation in patients with advanced heart failure compared to obesity?
Population
501 consecutive patients with advanced heart failure referred for heart transplant evaluation
Comparison
Morbid obesity (BMI ≥40 kg/m²) vs Obesity (BMI 30.1-40 kg/m²)
Design
Cohort
Authors
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Morbid obesity may worsen prognosis beyond the obesity paradox in advanced HF; hypothesis-generating and should not yet change practice.
Does morbid obesity increase the risk of all-cause mortality or transplantation in patients with advanced heart failure compared to obesity?
While the obesity paradox exists in advanced heart failure, it does not extend to morbidly obese patients, who face a significantly higher risk of mortality or transplantation compared to obese patients.
Nagarajan et al. (2013) studied this question.
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