Why the study?
Does carvedilol compared to metoprolol succinate affect peak exercise heart rate and norepinephrine levels in subjects with chronic heart failure?
Population
37 subjects with chronic heart failure referred for cardiopulmonary exercise testing
Comparison
Carvedilol (mean dose 32.9 +/- 3.5 mg daily) vs Metoprolol succinate
Design
Cohort
Authors
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Supports greater beta-1 blockade with metoprolol XL in HF; leaves open effects on exercise capacity or outcomes.
Does carvedilol compared to metoprolol succinate affect peak exercise heart rate and norepinephrine levels in subjects with chronic heart failure?
Metoprolol succinate at a mean daily dose of 96.4 mg provides more complete beta-1 blockade, evidenced by lower peak exercise heart rate, compared to carvedilol at 32.9 mg in chronic heart failure patients.
Vittorio et al. (2008) studied this question.
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