Why the study?
Does digoxin reduce beta-adrenergic contractile response in rabbit hearts?
Population
57 female Japanese White rabbits weighing between 2.5 and 3.2 kg
Comparison
Digoxin 0.3 mg/kg administered intravenously… vs Saline administered intravenously over 5 minutes
Design
Preclinical
Follow-up
up to 6 hours
Authors
Loading...
May blunt dobutamine responsiveness in rabbits; leaves open translation to digoxin effects on beta-adrenergic signaling in human HF.
Does digoxin reduce beta-adrenergic contractile response in rabbit hearts?
Digoxin rapidly reduces beta-adrenergic contractile response in rabbit hearts, likely reflecting an inhibition of adenylyl cyclase by Ca2+ mobilized via Na+/Ca2+ exchange.
Nagai et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: