Interaction of sequential stimuli applied during the relative refractory period in relation to determination of fibrillation threshold in the canine ventricle.
Why the study?
How do sequential stimuli applied during the relative refractory period interact to affect the ventricular fibrillation threshold in canine ventricles?
Population
Canine ventricle model
Comparison
Sequential electrical stimuli applied during the… vs Single stimuli or different timing of sequential…
Design
Preclinical
Authors
Discussion
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Overview
Stimulus interactions may alter VF threshold estimates in canine models; hypothesis-generating and should not yet inform clinical protocols.
Structured PICO
How do sequential stimuli applied during the relative refractory period interact to affect the ventricular fibrillation threshold in canine ventricles?
P
Population
Canine ventricle model
I
Intervention
Sequential electrical stimuli applied during the relative refractory period
C
Comparator
Single stimuli or different timing of sequential stimuli
O
Outcome
Response patterns of cardiac tissue (propagated response vs failure)surrogate
Sequential electrical stimuli during the relative refractory period can interact in complex ways, which has implications for assessing ventricular fibrillation thresholds using trains of stimuli.
Cite This Study
Tamargo et al. (1975) studied this question.