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February 1, 2017British journal of surgeryOpen Access

Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years

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Why the study?

Does elective endovascular aneurysm repair (EVAR) reduce mortality compared to open repair in patients with abdominal aortic aneurysm?

Population

2,783 patients with abdominal aortic aneurysm from 4 multicentre randomized trials (EVAR-1, DREAM, OVER, ACE)

Comparison

Elective endovascular aneurysm repair (EVAR) vs Open repair

Design

Meta-analysis

Follow-up

median 5.5 years

Authors

JPJanet T. PowellVascular MedicineMSMichael SweetingVascular MedicinePUPinar UlugImperial College London

Discussion

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Implication

EVAR's early mortality benefit warrants selective use in frail patients; confirms late aneurysm-related mortality excess versus open repair.

Structured PICO

Does elective endovascular aneurysm repair (EVAR) reduce mortality compared to open repair in patients with abdominal aortic aneurysm?

P
Population
2,783 patients with abdominal aortic aneurysm from 4 multicentre randomized trials (EVAR-1, DREAM, OVER, ACE)
I
Intervention
Elective endovascular aneurysm repair (EVAR)
C
Comparator
Open repair
O
Outcome
Mortality, aneurysm-related mortality and reinterventionhard clinical

EVAR offers an early survival advantage over open repair for abdominal aortic aneurysms, but this benefit is lost over time due to late aneurysm-related mortality.

Cite This Study

Powell et al. (2017) studied this question.

synapsesocial.com/papers/6a7ddc1afcc540eda03c94abhttps://doi.org/10.1002/bjs.10430
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