Population
Rat ventral root fibres (normal and demyelinated with diphtheria toxin)
Comparison
Trains of impulses, replacement of NaCl with… vs Normal fibres and baseline conditions
Design
Preclinical
Authors
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No immediate clinical implications for demyelinating disease; extends mechanistic insights in animal models but leaves human relevance open.
The study demonstrates that conduction block in demyelinated nerve fibers during impulse trains is caused by membrane hyperpolarization from electrogenic sodium pumping.
Bostock et al. (1985) studied this question.
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