Key result
Afferent fiber stimulation increases extracellular K+ and transiently shrinks spinal dorsal horn space up to ~75%.
Population
Spinal cord models (implied preclinical models)
Design
Preclinical
Authors
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May alter spinal synaptic transmission; hypothesis-generating for neuromodulation mechanisms in pain research.
Electrical stimulation and specific drugs modulate extracellular potassium and volume in the spinal cord, which may alter synaptic transmission.
Eva Syková (1987) studied Spinal cord transmission. Electrical stimulation and pharmacological agents was evaluated on Extracellular K+ activity and extracellular volume. Electrical stimulation of afferent fibres increases extracellular K+ activity up to 9-10 mM and induces transient shrinkage of extracellular space in spinal dorsal horns by 5-75%.
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