Why the study?
Does blockade of VEGF by sFlt-1 gene transfer reduce Angiotensin II-induced vascular inflammation and remodeling in wild-type mice?
Population
Wild-type mice infused with Angiotensin II
Comparison
Blockade of VEGF by soluble VEGF receptor 1 gene… vs Control
Design
Preclinical
Authors
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Does not support clinical translation of sFlt-1 gene transfer; hypothesis-generating for VEGF as mediator of Ang II-induced vascular remodeling independent of hypertension.
Does blockade of VEGF by sFlt-1 gene transfer reduce Angiotensin II-induced vascular inflammation and remodeling in wild-type mice?
VEGF is an essential mediator in Angiotensin II-induced vascular inflammation and structural changes, highlighting its proinflammatory role independent of hypertension.
Zhao et al. (2004) studied this question.
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