Prospective evaluation of the saline infusion test for excluding primary aldosteronism due to aldosterone-producing adenoma

317 patients screened in the PAPY study (comprising patients with baseline aldosterone/renin ratio > 40 and one every four patients not fulfilling this criterion)

Saline infusion test (infusion of 2 L of isotonic saline intravenously over 4 hours)

Accuracy for diagnosing primary aldosteronism (PA), aldosterone-producing adenoma (APA), or idiopathic hyperaldosteronism (IHA) measured by the area under the receiver-operator characteristic curves (AUC) of aldosterone values after SITsurrogate