Why the study?
Transient pulmonary congestion during exercise impairs exercise capacity in HFpEF, but whether an abnormal cardiac energetic state underpins this process was unknown.
Population
Patients across diastolic dysfunction and HFpEF: controls (n=11), type 2 diabetes (n=9), HFpEF (n=14), cardiac amyloidosis (n=9)
Comparison
Rest vs submaximal exercise across 4 groups of diastolic dysfunction and HFpEF
Design
Physiological cross-sectional study
Loading...
Energetic deficit may contribute to exercise congestion in HFpEF; hypothesis-generating and should not yet change practice.
A gradient of myocardial energetic deficit exists across the spectrum of HFpEF and is associated with abnormal exercise responses and detectable pulmonary congestion.
A 2021 study studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: