Why the study?
Does enalapril or atenolol improve collagen remodeling in the heart of Bio 14.6 Syrian hamsters?
Population
Male Bio 14.6 Syrian hamsters (76-79 days old)
Comparison
Low-dose enalapril, high-dose enalapril, or… vs Vehicle for 65 days; age and sex matched healthy…
Design
Preclinical
Follow-up
65 days
Authors
Loading...
Supports remodeling effects in hamster cardiomyopathy model; leaves open translation to human HF therapy.
Does enalapril or atenolol improve collagen remodeling in the heart of Bio 14.6 Syrian hamsters?
Enalapril and atenolol produce beneficial effects on collagen remodeling in cardiomyopathic hamsters by decreasing total collagen and altering collagen phenotypes.
Mansoor et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: