Why the study?
What is the incidence of neuroleptic malignant syndrome in psychiatric inpatients treated with a single antipsychotic agent?
Population
223 consecutive psychiatric in-patients, including 120 with schizophrenia and others with bipolar affective…
Design
Cohort
Follow-up
per admission and first neuroleptic exposure
Authors
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May warrant closer NMS monitoring in bipolar inpatients on injectables; leaves open confirmation of risk factors in larger prospective cohorts.
What is the incidence of neuroleptic malignant syndrome in psychiatric inpatients treated with a single antipsychotic agent?
The incidence of neuroleptic malignant syndrome in psychiatric inpatients on single antipsychotic therapy without anticholinergic prophylaxis is approximately 2.2%, with higher risk observed in bipolar patients and those receiving injections.
Hermesh et al. (1992) studied this question.
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