Key result
Hypertensive patients exhibited significantly lower serum antioxidant status (FRAP 61.37 vs 423 µmol/L, p<0.001) and higher oxidant load (FOX2 12.4 vs 4.33 µmol/L, p=0.001) than normotensive controls.
Why the study?
Recent studies implicate oxidative stress in the pathogenesis of hypertension, motivating an evaluation of oxidative stress in hypertensive subjects and its correlation with hypertension severity.
Is hypertension associated with lower serum antioxidant status and higher oxidant load compared to normotensive controls, and does antioxidant status correlate with hypertension severity?
Case-Control (n=192)
No
Is hypertension associated with lower serum antioxidant status and higher oxidant load compared to normotensive controls, and does antioxidant status correlate with hypertension severity?
Absolute Event Rate: 61.37% vs 423%
p-value: p=<0.001
Demonstrates a strong correlation between hypertension severity, dyslipidemia, increased serum oxidant load, and reduced serum antioxidant capacity, suggesting a potential role for oxidative stress in the pathophysiology of hypertension.
Background and objectives: Recent studies imply an increasing association of oxidative stress in the pathogenesis of hypertension.This study was designed to evaluate oxidative stress in hypertensive subjects and to assess the correlation of antioxidant status with the severity of hypertension.Material and methods: Ninety-six hypertensive cases were divided into three groups based on severity of hypertension as per JNC VII classification.Lipid profile, antioxidant power of serum(FRAP assay) and oxidant load of serum(FOX2) of hypertensive cases were compared with an equal number of age and sex matched healthy normotensive controls.Data was analysed by Student's t test and Pearson's correlation.Result: Lipid profile, oxidant load was significantly higher in hypertensive patients in comparison to controls (P<0.001).Antioxidant status was lower in hypertensives as compared to controls.A significant correlation was observed between lipid profile vs. oxidative stress and hypertension vs. low antioxidant level (r=0.835,P<0.001) Conclusion: Above findings demonstrate a strong association between blood pressure, dyslipidaemia and oxidative parameters shows a possible role of oxidative stress in the severity of hypertension.
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Rasmita Kumari Padhy (2012) conducted a case-control in Hypertension (n=192). Hypertension vs. Healthy normotensive controls (age and sex matched) was evaluated on Serum total antioxidant power (FRAP assay, in µmol/L equivalent of Ferrous Sulphate) (p=<0.001). Hypertensive patients exhibited significantly lower serum antioxidant status (FRAP 61.37 vs 423 µmol/L, p<0.001) and higher oxidant load (FOX2 12.4 vs 4.33 µmol/L, p=0.001) than normotensive controls.
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