October 1, 1989Journal of VirologyOpen Access

Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype

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Population

Weanling mice

Comparison

Inoculation with Theiler's murine… vs Inoculation with wild-type DA strain

Design

Preclinical

Authors

RRRaymond P. RoosNorthwestern University SSS SteinBiotechnology Research Center MRMark RoutbortThe University of Texas MD Anderson Cancer Center

Discussion

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Implication

Reduced demyelination by TMEV escape mutants in mice warrants mechanistic studies; hypothesis-generating for viral determinants of CNS disease.

Structured PICO

Population

Weanling mice

Intervention

Inoculation with Theiler's murine encephalomyelitis virus neutralization escape mutants (mutation in VP1 amino acid residue 268)

Comparator

Inoculation with wild-type DA strain

Outcome

Demyelinating disease phenotype

Neutralization escape mutants of Theiler's murine encephalomyelitis virus with a VP1 mutation lose their ability to cause demyelinating disease in mice.

Cite This Study

Roos et al. (1989) studied this question.

synapsesocial.com/papers/6a7e04c3f3499a80f78ca176 https://doi.org/10.1128/jvi.63.10.4469-4473.1989

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Implication

Reduced demyelination by TMEV escape mutants in mice warrants mechanistic studies; hypothesis-generating for viral determinants of CNS disease.

Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider