April 23, 2010Journal of Cardiovascular Electrophysiology

Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation

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Population

hERG-expressing Chinese Hamster Ovary cells

Comparison

Extracellular acidosis vs Normal external pH (7.4)

Design

Preclinical

Authors

CDCHUN YUN DUUniversity of Bristol IAIsmail AdeniranManchester Metropolitan University HCHongwei ChengUniversity of Bristol

Discussion

Member takes

Implication

Acidosis may heighten arrhythmia susceptibility via impaired hERG protection; animal data leave open human relevance.

Structured PICO

Population

hERG-expressing Chinese Hamster Ovary cells

Intervention

Extracellular acidosis (reducing external pH from 7.4 to 6.3)

Comparator

Normal external pH (7.4)

Outcome

hERG current (I(hERG)) characteristics and amplitude of outward I(hERG) transients elicited by premature stimulisurrogate

Extracellular acidosis impairs the protective role of hERG potassium channels, potentially increasing susceptibility to proarrhythmogenic depolarizing stimuli.

Cite This Study

DU et al. (2010) studied this question.

synapsesocial.com/papers/6a7e07c1968fa26fcacb5709 https://doi.org/10.1111/j.1540-8167.2010.01772.x

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Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider