Population
Xenopus oocytes expressing human ether-à-go-go-related gene (HERG)
Comparison
Extracellular acidification (pH 8.5 to 6.5) vs Different extracellular pH levels
Design
Preclinical
Authors
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May link acidosis to repolarization changes; leaves open translation to human arrhythmia risk.
Extracellular acidification accelerates HERG channel deactivation via extracellularly accessible side chains, providing a mechanism for altered cardiac electrical activity during pathological acidosis.
Jiang et al. (1999) studied this question.
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