January 1, 1995Biochemistry
Eosin, a Potent Inhibitor of the Plasma Membrane Ca Pump, Does Not Inhibit the Cardiac Na-Ca Exchanger
Population
Cardiac myocytes and human red cell membranes (preclinical models)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Eosin may enable selective probing of cardiac Ca homeostasis in experimental models; leaves open validation beyond isolated preparations.
Structured PICO
P
Population
Cardiac myocytes and human red cell membranes (preclinical models)
I
Intervention
Eosin (tetrabromofluorescein)
O
Outcome
Inhibition of the cardiac sarcolemmal/plasma membrane (SL(PM)) Ca pump and the Na-Ca exchangersurrogate
Eosin is a potent, selective inhibitor of the plasma membrane Ca pump and can be used as a tool to study whole cell Ca homeostasis without affecting the Na-Ca exchanger.
Cite This Study
Gatto et al. (1995) studied this question.