Population
Xenopus oocytes expressing slowly activating IsK channels and IsK protein mutants
Comparison
Exposure to oxidative agents (peroxides) and Hg2+ vs IsK protein mutants
Design
Preclinical
Authors
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Delineates distinct intra- and extracellular IsK regulatory sites; extends molecular channel biology but leaves open in vivo cardiac relevance.
This study demonstrates that IsK channels are dually regulated by intracellular oxidation (causing inhibition) and extracellular chelation by Hg2+ (causing activation).
Büsch et al. (1995) studied this question.
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