November 1, 1983Cardiovascular Research

Ischaemia-induced changes in canine cardiac sarcoplasmic reticulum

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Population

Canine model (dog hearts)

Comparison

Regional myocardial ischemia produced by… vs Control (non-ischemic) areas of the same hearts

Design

Preclinical

Follow-up

60 minutes

Authors

KIKunio ImaiMie University TWTingzhong WangElectrophysiology RMR. W. MillardFlorida Atlantic University

Discussion

Member takes

Implication

Highlights potential mechanism for early ischemic dysfunction; hypothesis-generating and requires human validation before clinical relevance.

Structured PICO

Population

Canine model (dog hearts)

Intervention

Regional myocardial ischemia produced by occlusion of the left circumflex artery for up to 60 minutes

Comparator

Control (non-ischemic) areas of the same hearts

Outcome

In vitro activities of sarcoplasmic reticulum (calcium transport, Ca2+-ATPase, Ca2+ binding, and cAMP-dependent phosphorylation)surrogate

Regional myocardial ischemia rapidly impairs sarcoplasmic reticulum calcium handling in the subendocardium, potentially contributing to ischemic ventricular dysfunction.

Cite This Study

Imai et al. (1983) studied this question.

synapsesocial.com/papers/6a7e18e7bcaf28b5c937ed5b https://doi.org/10.1093/cvr/17.11.696

View Full Paper

Ask AI

Bookmark

Implication

Highlights potential mechanism for early ischemic dysfunction; hypothesis-generating and requires human validation before clinical relevance.

Ischaemia-induced changes in canine cardiac sarcoplasmic reticulum

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ischaemia-induced changes in canine cardiac sarcoplasmic reticulum

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider