Population
Rat hippocampal neurons (in situ and in culture) and cells transfected with Kv2.1 cDNA
Comparison
KC antibody specific for the Kv2.1 K+ channel… vs Antibodies to two other K+ channel…
Design
Preclinical
Authors
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KC antibody specifically targets Kv2.1 currents in hippocampal neurons; leaves open its utility for dissecting channel roles in intact circuits.
Kv2.1 is a major contributor to the delayed rectifier K+ current in hippocampal neurons, and the KC antibody effectively blocks this current.
Murakoshi et al. (1999) studied this question.
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