Relationship Between Platelet Reactivity and Ischemic and Bleeding Events After Percutaneous Coronary Intervention in East Asian Patients: 1‐Year Results of the PENDULUM Registry
Why the study?
The balance between ischemic and bleeding events and their relationship with platelet reactivity on antiplatelet therapy after PCI was not fully evaluated in East Asians.
Does high platelet reactivity increase the risk of MACCE and major bleeding in Japanese patients undergoing PCI?
Population
6267 Japanese patients undergoing PCI
Comparison
High PRU (>208) vs optimal PRU (>85 to ≤208) vs low PRU (≤85)
Design
Prospective, multicenter registry
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
High PRU associated with higher MACCE after PCI in Japanese patients; leaves open whether reactivity testing should guide therapy.
Structured PICO
Does high platelet reactivity increase the risk of MACCE and major bleeding in Japanese patients undergoing PCI?
P
Population
6,267 Japanese patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents
I
Intervention
High platelet reactivity (P2Y12 reaction unit [PRU] >208) measured at 12 to 48 hours post-PCI
C
Comparator
Optimal platelet reactivity (PRU >85 to ≤208)
O
Outcome
Incidence of first major adverse cardiac and cerebrovascular events (MACCE) and first major bleeding events at 12 months post-PCIcomposite
In Japanese patients undergoing PCI, high platelet reactivity is associated with an increased risk of major adverse cardiac and cerebrovascular events at 1 year, without a significant difference in major bleeding.
Cite This Study
Nakamura et al. (2020) studied this question.