Key result
A P2Y12 reaction unit (PRU) value ≤ 153 at 12-48 hours after percutaneous coronary intervention was associated with a significantly lower risk of non-fatal ischemic stroke at 12 months (HR 0.43).
Why the study?
In patients undergoing PCI with a stent, high on-treatment platelet reactivity may be associated with an increased risk of stroke.
Does high on-treatment platelet reactivity increase the risk of non-fatal stroke in patients undergoing percutaneous coronary intervention?
Population
5906 PCI patients aged >= 20 years with PRU data from the PENDULUM registry
Comparison
High (PRU > 208) vs optimal (PRU > 85 to <= 208) vs low on-treatment platelet reactivity (PRU <= 85)
Design
Post hoc registry analysis
Follow-up
12 months
Authors
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High PRU may flag elevated post-PCI stroke risk; hypothesis-generating for PRU-guided therapy trials.
Observational (n=5,906)
Yes
Does high on-treatment platelet reactivity increase the risk of non-fatal stroke in patients undergoing percutaneous coronary intervention?
Hazard Ratio: 0.43 (95% CI 0.19–0.98)
p-value: p=0.044
High on-treatment platelet reactivity (PRU > 153) at 12-48 hours post-PCI is associated with an increased risk of non-fatal ischemic stroke at 12 months in Japanese patients.
Matsumaru et al. (2022) conducted an observational in percutaneous coronary intervention (PCI) with a stent (n=5,906). P2Y12 reaction unit (PRU) ≤ 153 vs. PRU > 153 was evaluated on Non-fatal ischemic stroke at 12 months (HR 0.43, 95% CI 0.19-0.98, p=0.044). A P2Y12 reaction unit (PRU) value ≤ 153 at 12-48 hours after percutaneous coronary intervention was associated with a significantly lower risk of non-fatal ischemic stroke at 12 months (HR 0.43).
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