Why the study?
Does prescription of NSAIDs increase the risk of first-diagnosed episode of heart failure in individuals aged 40-84 years?
Population
5,857 individuals aged 40-84 years without prior heart failure or cancer, registered in the U.K. General…
Comparison
Prescription of nonsteroidal antiinflammatory… vs No NSAID prescription
Design
Case-control
Follow-up
Up to 1 year (January 1, 1996 to December 31, 1996)
Authors
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Supports caution prescribing NSAIDs to adults at HF risk; leaves open causal confirmation in prospective trials.
Does prescription of NSAIDs increase the risk of first-diagnosed episode of heart failure in individuals aged 40-84 years?
Prescription of NSAIDs is associated with a significantly increased risk of incident heart failure, particularly in patients with preexisting hypertension, diabetes, or renal failure.
Rodrı́guez et al. (2003) studied this question.
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