Key result
Recent NSAID use shows no significant association with first CHF admission.
Why the study?
It is unclear whether the risk of congestive heart failure associated with NSAIDs and selective COX-2 inhibitors differs between first-time and recurrent cases of CHF.
Does recent use of NSAIDs or selective COX-2 inhibitors increase the risk of hospitalization for congestive heart failure?
Population
530 CHF cases (285 first-time, 245 recurrent) and 1,054 controls admitted to same hospitals, frequency matched by age and sex
Comparison
Recent use of NSAIDs or selective COX-2 inhibitors vs non-use
Design
Case-control study with structured interviews and adjusted relative risk estimation
Authors
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Does not support altering NSAID use in CHF; leaves open causal risk from this Level 4 evidence.
Case-Control (n=1,584)
Yes
Does recent use of NSAIDs or selective COX-2 inhibitors increase the risk of hospitalization for congestive heart failure?
Relative Risk: 1.1 (95% CI 0.67–1.83)
Recent use of NSAIDs and COX-2 inhibitors showed a weak, statistically nonsignificant association with first-time CHF hospitalization, while significantly lower prescribing rates in recurrent CHF cases suggest physician awareness of their cardiovascular risks.
McGettigan et al. (2008) conducted a case-control in congestive heart failure (CHF) (n=1,584). NSAIDs and selective COX-2 inhibitors vs. No recent use was evaluated on First hospital admission for CHF (RR 1.1, 95% CI 0.67-1.83). Recent use of NSAIDs showed a weak, nonsignificant association with first CHF admission (RR 1.1; 95% CI 0.67-1.83), but use was significantly higher in first-time versus recurrent cases (P=0.0004).
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