February 11, 2002Archives of Internal Medicine
Association of Nonsteroidal Anti-inflammatory Drugs With First Occurrence of Heart Failure and With Relapsing Heart Failure
Why the study?
Does the use of NSAIDs increase the risk of incident heart failure or relapsing heart failure?
Population
7,277 participants in the Rotterdam Study without prevalent heart failure at baseline, and a subset of…
Comparison
Current use of nonsteroidal anti-inflammatory… vs Non-use of NSAIDs.
Design
Cohort
Authors
Discussion
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Member takes
Implication
NSAID avoidance may be prudent in prevalent HF; leaves open causal confirmation in randomized studies.
Structured PICO
Does the use of NSAIDs increase the risk of incident heart failure or relapsing heart failure?
P
Population
7,277 participants in the Rotterdam Study without prevalent heart failure at baseline, and a subset of participants with incident heart failure.
I
Intervention
Current use of nonsteroidal anti-inflammatory drugs (NSAIDs) based on filled drug prescriptions.
C
Comparator
Non-use of NSAIDs.
O
Outcome
First occurrence of incident heart failure, and first relapse of heart failure.hard clinical
NSAID use does not increase the risk of first-time heart failure but substantially increases the risk of heart failure relapse in patients with pre-existing disease.
Cite This Study
Heerdink et al. (2002) studied this question.