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January 19, 2016Proceedings of the National Academy of SciencesOpen Access

Discovery of RNA splicing and genes in pieces

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Authors

ABArnold BerkUniversity of California, Los Angeles

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Implication

Historical review uncovers the discovery of split genes in eukaryotic cells, highlighting fundamental mechanisms of RNA splicing.

Key Points

  • Examine the foundational milestones and structural insights surrounding the discovery of discontinuous eukaryotic genes and RNA splicing.
  • Reviewed historical molecular biology findings that revealed non-contiguous gene organization and pre-mRNA transcript maturation.
  • Demonstrated that eukaryotic genes are structurally discontinuous, containing expressed sequences interrupted by intervening non-coding regions.
  • Identified the cellular mechanism that excises intervening segments and ligates remaining sequences to produce functional messenger RNA.

Cite This Study

Arnold Berk (2016) studied this question.

synapsesocial.com/papers/6a7e2216b7d9fb789ca2a30fhttps://doi.org/10.1073/pnas.1525084113
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