Why the study?
Does antihypertensive drug treatment reduce the incidence of major complications in men with diastolic blood pressure 90-114 mm Hg?
Does antihypertensive drug treatment reduce the incidence of major complications in men with diastolic blood pressure 90-114 mm Hg?
Antihypertensive drug treatment significantly reduces the risk of major morbid events in men with diastolic blood pressure of 90-114 mm Hg, with benefits proportional to baseline risk.
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May support treatment in moderate hypertension; leaves open need for contemporary RCTs in diverse groups.
Progress in the development of effective antihypertensive agents is briefly reviewed. Evidence that drug treatment reduces the incidence of major complications is presented. The recently completed controlled trial carried out in Veterans Administration hospitals indicates that in men with diastolic blood pressure levels of 90 through 114 mm Hg the risk of developing a morbid event over a five-year period was reduced from 55% to 18% by treatment. The degree of benefit was proportional to the risk, which in turn was related directly to the level of blood pressure.
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E. D. Freis (1971) studied this question.
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