May 27, 2005Arteriosclerosis Thrombosis and Vascular Biology
No Effect of C-Reactive Protein on Early Atherosclerosis Development in Apolipoprotein E*3-Leiden/Human C-Reactive Protein Transgenic Mice
Why the study?
Does mildly elevated human CRP contribute to early atherosclerosis development in hypercholesterolemic E3L mice?
Population
15 male and 15 female apolipoprotein E*3-Leiden transgenic mice carrying the human CRP gene and E3L…
Comparison
Expression of human CRP gene vs E3L transgenic littermates
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not support CRP causality in early atherosclerosis; leaves open its human role and requires further translational studies.
Structured PICO
Does mildly elevated human CRP contribute to early atherosclerosis development in hypercholesterolemic E3L mice?
P
Population
15 male and 15 female apolipoprotein E*3-Leiden (E3L) transgenic mice carrying the human CRP gene (E3L/CRP) and E3L transgenic littermates, fed a hypercholesterolemic diet
I
Intervention
Expression of human CRP gene (E3L/CRP transgenic model)
C
Comparator
E3L transgenic littermates (controls without human CRP gene)
O
Outcome
Atherosclerosis development (quantification of lesion area)surrogate
Mildly elevated levels of human CRP do not contribute to the development of early atherosclerosis in a hypercholesterolemic transgenic mouse model.
Cite This Study
Trion et al. (2005) studied this question.