Key result
Expression of human C-reactive protein in LDLR-/- mice did not significantly alter atherosclerotic lesion size or composition compared to huCRP-negative controls.
Why the study?
Does human C-reactive protein expression promote early atherosclerosis in LDLR-/- mice fed a Western type diet?
Does human C-reactive protein expression promote early atherosclerosis in LDLR-/- mice fed a Western type diet?
Expression of human C-reactive protein does not promote early atherosclerotic lesion development in LDLR-/- mice, suggesting CRP may not play a direct pathogenetic role in early atherogenesis.
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Does not support CRP as a therapeutic target in early atherosclerosis; leaves open its role in human disease or advanced lesions.
Cheng et al. (2007) studied Atherosclerosis. Human CRP pentraxin (huCRP) expression vs. huCRP-negative LDLR-/- controls was evaluated on Atherosclerotic lesion size and composition. Expression of human C-reactive protein in LDLR-/- mice did not significantly alter atherosclerotic lesion size or composition compared to huCRP-negative controls.
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