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April 18, 2013Clinical ChemistryOpen Access

Plasma proANP Decreases after Meal Intake

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Why the study?

Does meal intake reduce plasma proANP and proBNP concentrations in healthy young individuals?

Population

6 healthy young individuals between 20 and 30 years of age, with no known disease and free of medication.

Comparison

Meal intake vs Baseline fasting state

Design

Other

Follow-up

3 hours

Authors

JGJens P. GoetzeHeart Failure / Cardiomyopathy

Discussion

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Member takes

Overview

Recent meal intake may lower proANP and risk false-negative HF readings; leaves open fasting standardization in broader cohorts.

Structured PICO

Does meal intake reduce plasma proANP and proBNP concentrations in healthy young individuals?

P
Population
6 healthy young individuals between 20 and 30 years of age (2 men and 4 women), with no known disease and free of medication.
I
Intervention
Meal intake (1500 calories total: 250 g roast beef, 300 g oven-baked potatoes in cream sauce, 1 bread roll, and 250 mL orange juice)
C
Comparator
Baseline fasting state (concentrations at -10 min and 0 min)
O
Outcome
Plasma proANP and proBNP concentrations over 3 hourssurrogate

Meal intake significantly decreases plasma proANP concentrations, suggesting that clinical measurements of proANP for heart failure diagnosis should be performed in the fasting state to avoid false negatives.

Cite This Study

Jens P. Goetze (2013) studied this question.

synapsesocial.com/papers/6a7e294bdeca64d61c3c362dhttps://doi.org/10.1373/clinchem.2012.202416
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