What does this research mean for the field?

Bed rest induces a marked decrease in plasma proANP concentrations, but neither acute hyperinsulinemia, hyperglucagonemia, nor early impaired glucose regulation affect proANP levels, suggesting that decreased proANP occurs late in the development of insulin resistance. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 2017EBioMedicineOpen Access

Effect of Pancreatic Hormones on pro-Atrial Natriuretic Peptide in Humans

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Why the study?

Do acute hyperinsulinemia, hyperglucagonemia, or bed rest affect plasma proANP concentrations in humans?

Population

81 individuals across three studies: 6 healthy men, 65 individuals with normal or impaired glucose…

Comparison

7 days of bed rest, hyperinsulinemic euglycemic… vs Baseline and normal glucose regulation

Follow-up

7 days (for bed rest study)

Authors

NZNora Elisabeth ZoisGubra (Denmark)DTDijana TerzicCopenhagen University Hospital KFKristine FærchSteno Diabetes Centers

Discussion

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Implication

Acute insulin/glucagon changes do not affect proANP; hypothesis-generating for late reductions in chronic insulin resistance.

Structured PICO

Do acute hyperinsulinemia, hyperglucagonemia, or bed rest affect plasma proANP concentrations in humans?

Population

81 individuals across three studies: 6 healthy men (bed rest study), 65 individuals with normal or impaired glucose regulation, and 10 healthy men (hyperglucagonemia study).

Intervention

7 days of bed rest, hyperinsulinemic euglycemic clamps, and infusion-induced hyperglucagonemia

Comparator

Baseline (before bed rest) and normal glucose regulation

Outcome

Plasma proANP concentrationssurrogate

Acute changes in insulin or glucagon do not affect proANP levels, suggesting that the decreased proANP seen in insulin resistance develops late in the disease process.

Cite This Study

Zois et al. (2017) studied this question.

synapsesocial.com/papers/6a1bec0626cb5670aa9d1d5a https://doi.org/10.1016/j.ebiom.2017.02.026

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Effect of Pancreatic Hormones on pro-Atrial Natriuretic Peptide in Humans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Pancreatic Hormones on pro-Atrial Natriuretic Peptide in Humans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider