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September 12, 2008Clinical ChemistryOpen Access

Impact of Epitope Specificity and Precursor Maturation in Pro-B–Type Natriuretic Peptide Measurement

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Why the study?

Do different proBNP assays with varying epitope specificities perform comparably in diagnosing reduced LVEF and predicting long-term mortality in elderly patients with heart failure symptoms?

Population

Randomly collected human plasma specimens and a cohort of elderly patients presenting with symptoms…

Comparison

Measurement using 4 different proBNP assays with… vs Comparison among the different assays

Design

Cohort

Authors

JGJens P. GoetzeHeart Failure / CardiomyopathyUDUlf DahlströmHeart Failure / CardiomyopathyJRJens F. RehfeldUniversity of Copenhagen

Discussion

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Overview

Comparable assay performance may permit flexible proBNP testing for reduced LVEF in elderly HF patients; leaves open prognostic equivalence across assays.

Structured PICO

Do different proBNP assays with varying epitope specificities perform comparably in diagnosing reduced LVEF and predicting long-term mortality in elderly patients with heart failure symptoms?

P
Population
Randomly collected human plasma specimens (n=370) and a cohort of elderly patients presenting with symptoms associated with heart failure (n=415)
I
Intervention
Measurement using 4 different proBNP assays with varying epitope specificities (including N-terminal proBNP and proBNP 1-76)
C
Comparator
Comparison among the different assays
O
Outcome
Correlation between assay measurements, identification of reduced left ventricular ejection fraction (ROC AUC), and prediction of long-term mortalitysurrogate

Despite analytical differences between proBNP assays with different epitope specificities, their clinical performance in diagnosing reduced LVEF and predicting prognosis in elderly patients with heart failure symptoms is comparable.

Cite This Study

Goetze et al. (2008) studied this question.

synapsesocial.com/papers/6a7e294bdeca64d61c3c362ehttps://doi.org/10.1373/clinchem.2008.105635
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Also Consider

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  1. 1Use of B-Type Natriuretic Peptide in the Evaluation and Management of Acute Dyspnea2004 · 1,008 citations
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  3. 3Cross-Reactivity of BNP, NT-proBNP, and proBNP in Commercial BNP and NT-proBNP Assays: Preliminary Observations from the IFCC Committee for Standardization of Markers of Cardiac Damage2008 · 134 citations
  4. 4Plasma pro-B-type natriuretic peptide in the general population: screening for left ventricular hypertrophy and systolic dysfunction2006 · 94 citations
  5. 5Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005)2005 · 2,271 citations