January 1, 2001Thrombosis and Haemostasis
Extracellular Nucleotides ATP and UTP Induce a Marked Acute Release of Tissue-type Plasminogen Activator In Vivo in Man
Why the study?
Do extracellular nucleotides ATP and UTP induce acute tPA release from the vascular endothelium in healthy subjects?
Population
9 healthy subjects studied in a perfused-forearm model
Comparison
Stepwise intraarterial infusions of ATP and UTP… vs Baseline (pre-infusion)
Design
Other
Follow-up
Acute (during infusion)
Authors
Discussion
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Member takes
Implication
Supports nucleotide involvement in vascular fibrinolysis; leaves open clinical translation in ischemic patients.
Structured PICO
Do extracellular nucleotides ATP and UTP induce acute tPA release from the vascular endothelium in healthy subjects?
P
Population
9 healthy subjects studied in a perfused-forearm model
I
Intervention
Stepwise intraarterial infusions of ATP and UTP (10-200 nmol/min), and UTP during inhibition of prostanoid and NO synthesis by indomethacin and L-NMMA
C
Comparator
Baseline (pre-infusion)
O
Outcome
Forearm tissue-type plasminogen activator (tPA) releasesurrogate
Extracellular nucleotides ATP and UTP induce marked acute release of tPA and vasodilation in vivo, suggesting they may activate the endogenous fibrinolytic system during ischemic tissue injury.
Cite This Study
Hrafnkelsdóttir et al. (2001) studied this question.