July 1, 1999Cardiovascular Research

Enhanced acetylcholine and P2Y-receptor stimulated vascular EDHF-dilatation in congestive heart failure

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Population

Sprague Dawley rats with congestive heart failure induced by left coronary artery ligation

Comparison

Acetylcholine and extracellular nucleotides… vs Sham operated rats

Design

Preclinical

Authors

MMMalin MalmsjöSkåne University Hospital

Discussion

Member takes

Implication

Should not change clinical practice; leaves open EDHF compensation as hypothesis-generating for human endothelial studies in CHF.

Structured PICO

Population

Sprague Dawley rats with congestive heart failure (CHF) induced by left coronary artery ligation (myocardial infarction model)

Intervention

Acetylcholine and extracellular nucleotides (ATP, ADP beta S, ADP and UTP) applied to cylindrical segments of the mesenteric artery, precontracted with noradrenaline

Comparator

Sham operated rats

Outcome

Vasodilatory responses (EDHF-dilatation, NO-dilatation, and total dilatation)surrogate

In a rat model of non-atherosclerotic CHF, EDHF-mediated vasodilation is up-regulated, potentially as a compensatory mechanism for decreased NO-activity to preserve endothelial function.

Cite This Study

Malin Malmsjö (1999) studied this question.

synapsesocial.com/papers/6a844e3331983d826d0bb30c https://doi.org/10.1016/s0008-6363(99)00062-0

Topics

Heart failure HFrEF treatment

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Enhanced acetylcholine and P2Y-receptor stimulated vascular EDHF-dilatation in congestive heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Enhanced acetylcholine and P2Y-receptor stimulated vascular EDHF-dilatation in congestive heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider