Population
Xenopus laevis oocytes (uninjected or injected with cRNA encoding for K+ channels: IsK, Kv1.1, or IRK1)
Comparison
Isosorbide dinitrate (ISDN) (1 mM) vs Other NO donors, Ba2+, or baseline
Design
Preclinical
Authors
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ISDN's NO-independent K+ channel block in oocytes warrants caution interpreting its effects in models; leaves open relevance to mammalian cardiac electrophysiology.
ISDN inhibits specific potassium channels in Xenopus oocytes through a mechanism independent of nitric oxide.
Büsch et al. (1996) studied this question.
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