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October 1, 1999International Journal of Oncology62 citations

Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells.

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Population

Cultured smooth muscle cells (SMCs)

Comparison

Resveratrol (50-100 microM) vs Untreated cells or cells treated with mitogens…

Design

Preclinical

Authors

JZJing ZouYHYing HuangQCQi Chen

Discussion

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Overview

Resveratrol inhibits smooth muscle cell proliferation via a G1 to S phase cell cycle block, suggesting potential anti-atherosclerotic properties.

Structured PICO

P
Population
Cultured smooth muscle cells (SMCs)
I
Intervention
Resveratrol (50-100 microM)
C
Comparator
Untreated cells or cells treated with mitogens alone (serum, endothelin, PDGF)
O
Outcome
SMC proliferation and cell cycle traversesurrogate

Resveratrol inhibits smooth muscle cell proliferation via a G1 to S phase cell cycle block, suggesting potential anti-atherosclerotic properties.

Cite This Study

Zou et al. (1999) studied this question.

synapsesocial.com/papers/6a7e431e19e76f2bf2990ac8https://doi.org/10.3892/ijo.15.4.647
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resveratrol modulates signalling to inhibit vascular smooth muscle cell proliferation induced by angiotensin II and high glucose2024 · 1 citations
  2. 2Resveratrol Inhibits Monocytic Cell Chemotaxis to MCP-1 and Prevents Spontaneous Endothelial Cell Migration Through Rho Kinase-Dependent Mechanism2011 · 25 citations
  3. 3Resveratrol and Vascular Function2019 · 199 citations
  4. 4Distinct Anti-Migratory Effects of Resveratrol on EGF- versus PDGF-Stimulated Vascular Smooth Muscle Cells2009
  5. 5EFFECTS OF RESVERATROL ON NUMBER AND ACTIVITY OF ENDOTHELIAL PROGENITOR CELLS FROM HUMAN PERIPHERAL BLOOD2007 · 54 citations