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June 26, 2007Clinical and Experimental Pharmacology and Physiology

Effects of Resveratrol on Number and Activity of Endothelial Progenitor Cells From Human Peripheral Blood

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Why the study?

Does resveratrol improve proliferation, migration, and vasculogenesis in human endothelial progenitor cells in vitro?

Population

Endothelial progenitor cells (EPC) isolated from human peripheral blood

Comparison

Resveratrol incubated for specified times vs Vehicle control

Design

Preclinical

Follow-up

24 hours

Authors

XWXiao‐Bin WangJHJun HuangJZJiangang Zou

Discussion

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Overview

In vitro EPC proliferation with resveratrol leaves open any human cardiovascular benefit; in vivo trials required before clinical consideration.

Structured PICO

Does resveratrol improve proliferation, migration, and vasculogenesis in human endothelial progenitor cells in vitro?

P
Population
Endothelial progenitor cells (EPC) isolated from human peripheral blood
I
Intervention
Resveratrol (1, 10, 25 and 50 mmol/L) incubated for specified times
C
Comparator
Vehicle control
O
Outcome
Cell proliferation, migration, and in vitro vasculogenesissurrogate

Resveratrol significantly induces endothelial progenitor cell proliferation, migration, and angiogenesis in vitro, suggesting a potential mechanism for its cardiovascular benefits.

Cite This Study

Wang et al. (2007) studied this question.

synapsesocial.com/papers/6a767cfeb8e2d3128429578chttps://doi.org/10.1111/j.1440-1681.2007.04667.x
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