July 18, 2011Clinical ChemistryOpen Access

ProBNP1–108 Is Resistant to Degradation and Activates Guanylyl Cyclase-A with Reduced Potency

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Why the study?

Does proBNP(1-108) differ from BNP(1-32) in receptor activation and degradation in vitro?

Population

In vitro models using human natriuretic peptide receptor populations and human kidney membranes

Comparison

Recombinant human proBNP(1-108) vs Human synthetic BNP(1-32)

Design

Preclinical

Authors

DDDeborah M. DickeyUniversity of Minnesota LPLincoln R. PotterUniversity of Minnesota System

Discussion

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Implication

May refine HF biomarker interpretation; leaves open proBNP's net in vivo contribution to GC-A signaling.

Structured PICO

Does proBNP(1-108) differ from BNP(1-32) in receptor activation and degradation in vitro?

Population

In vitro models using human natriuretic peptide receptor populations and human kidney membranes

Intervention

Recombinant human proBNP(1-108)

Comparator

Human synthetic BNP(1-32)

Outcome

Binding and activation of human natriuretic peptide receptors (GC-A, GC-B, clearance receptor) and degradation by human kidney membranessurrogate

ProBNP(1-108) is bioactive but less potent than BNP(1-32) and is resistant to degradation, which may explain its increased serum ratio in heart failure.

Cite This Study

Dickey et al. (2011) studied this question.

synapsesocial.com/papers/6a7e43d77b9c0a0182b7aee3 https://doi.org/10.1373/clinchem.2011.169151

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ProBNP1–108 Is Resistant to Degradation and Activates Guanylyl Cyclase-A with Reduced Potency

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ProBNP1–108 Is Resistant to Degradation and Activates Guanylyl Cyclase-A with Reduced Potency

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider