April 1, 1978Clinical Pharmacology & Therapeutics

Relationship between diazepam dose, plasma level, age, and central nervous system depression

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Why the study?

Does age correlate with the required dose and plasma level of diazepam for CNS depression in patients undergoing elective cardioversion?

Population

Patients undergoing elective cardioversion for treatment of arrhythmias

Design

Cross-sectional

Authors

HWHoward WarnerWashington University in St. Louis CCClaude B. CoutinhoRoche (Switzerland)GYGeorge YüPfizer (United States)

Discussion

Member takes

Implication

May support lower diazepam dosing in elderly cardioversion patients; hypothesis-generating and requires prospective validation.

Structured PICO

Does age correlate with the required dose and plasma level of diazepam for CNS depression in patients undergoing elective cardioversion?

Population

Patients undergoing elective cardioversion for treatment of arrhythmias

Intervention

Diazepam premedication (individualized dose to achieve CNS depression characterized by response to painful but not vocal stimulation)

Outcome

Plasma diazepam concentration (measured by gas chromatography) and its correlation with dose, age, and CNS depressionsurrogate

Age is a critical factor in diazepam dosing for cardioversion, as elderly patients require lower doses and plasma levels to achieve adequate CNS depression.

Cite This Study

Warner et al. (1978) studied this question.

synapsesocial.com/papers/6a7e450aaebfb5e3a74c44da https://doi.org/10.1002/cpt1978234371

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Relationship between diazepam dose, plasma level, age, and central nervous system depression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship between diazepam dose, plasma level, age, and central nervous system depression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider