June 1, 1999The Journal of General PhysiologyOpen Access

Kvβ1.2 Subunit Coexpression in HEK293 Cells Confers O2 Sensitivity to Kv4.2 but not to Shaker Channels

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Population

Transfected HEK293 cells

Design

Preclinical

Authors

MPM. Teresa Pérez‐GarcíaUniversidad de Valladolid JLJosé R. López‐LópezUniversidad de Valladolid CGConstancio GonzálezUniversidad de Valladolid

Discussion

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Implication

Hypothesis-generating for Kvβ1.2 control of Kv4.2 hypoxia sensitivity; leaves open relevance to native mammalian channels.

Structured PICO

Population

Transfected HEK293 cells

Intervention

Kvbeta1.2 subunit coexpression

Outcome

Electrophysiological properties of Shaker and Kv4.2 KV channel alpha subunits (inactivation rate, amplitude, sensitivity to redox modulation and hypoxia)surrogate

The Kvbeta1.2 subunit modulates different properties of KV channels depending on the alpha subunit, notably conferring hypoxia sensitivity to Kv4.2 channels.

Cite This Study

Pérez‐García et al. (1999) studied this question.

synapsesocial.com/papers/6a7e4648567bd3ec6fb7b0cd https://doi.org/10.1085/jgp.113.6.897

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Kvβ1.2 Subunit Coexpression in HEK293 Cells Confers O2 Sensitivity to Kv4.2 but not to Shaker Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Kvβ1.2 Subunit Coexpression in HEK293 Cells Confers O2 Sensitivity to Kv4.2 but not to Shaker Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider