Population
Rat phaeochromocytoma PC12 clonal cell line and Xenopus oocytes
Comparison
Hypoxia, charybdotoxin, and anti-Kv1.2 antibody vs Normoxia, anti-Kv2.1 antibody, and irrelevant…
Design
Preclinical
Authors
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Implicates Kv1.2 in cellular hypoxia sensing; leaves open validation in mammalian cardiovascular models.
The Kv1.2 alpha-subunit is a critical component of O2-sensitive K+ channels in PC12 cells, mediating the cellular response to hypoxia.
Conforti et al. (2000) studied this question.
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