Key result
Hypoxia reversibly inhibited heteromeric Kv1.2/Kv1.5 and Kv2.1/Kv9.3 channels in the voltage range of the resting membrane potential, identifying them as candidates for initiating hypoxic pulmonary vasoconstriction.
Population
Mouse L cells expressing cloned voltage-gated K+ channels (Kv1.2, Kv1.5, Kv2.1, and Kv9.3 alpha subunits)
Comparison
Hypoxia (PO2 = approximately 30 mm Hg) vs Baseline/normoxic conditions
Design
Preclinical
Authors
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May inform targeted PH therapies; leaves open which Kv channels mediate HPV.
Heteromeric Kv1.2/Kv1.5 and Kv2.1/Kv9.3 channels are inhibited by hypoxia at physiologically relevant membrane potentials, making them strong candidates for initiating hypoxic pulmonary vasoconstriction.
Hulme et al. (1999) studied Hypoxic pulmonary vasoconstriction. Hypoxia was evaluated on Kv channel current inhibition. Hypoxia reversibly inhibited heteromeric Kv1.2/Kv1.5 and Kv2.1/Kv9.3 channels in the voltage range of the resting membrane potential, identifying them as candidates for initiating hypoxic pulmonary vasoconstriction.
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