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October 15, 1996The Journal of PhysiologyOpen Access

Properties of a novel K+ current that is active at resting potential in rabbit pulmonary artery smooth muscle cells.

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Population

Rabbit pulmonary artery smooth muscle cells (myocytes)

Design

Preclinical

Authors

AEAllan M. EvansUniversity of South AustraliaOOO. N. OsipenkoKyiv City Clinical Oncology CenterAGAlison M. GurneyManchester Academic Health Science Centre

Discussion

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Implication

Does not support clinical translation; leaves open IK(N) contribution to human pulmonary vascular tone.

Structured PICO

P
Population
Rabbit pulmonary artery smooth muscle cells (myocytes)
I
Intervention
Electrophysiological characterization using voltage clamping and pharmacological agents (TEA, glibenclamide, 4-aminopyridine, quinine)
O
Outcome
Electrophysiological and pharmacological properties of the outward current IK(N)surrogate

A novel voltage-gated K+ current (IK(N)) was identified in rabbit pulmonary artery smooth muscle cells, which likely contributes to their resting membrane potential.

Cite This Study

Evans et al. (1996) studied this question.

synapsesocial.com/papers/6a197ee6c05413006f586b38https://doi.org/10.1113/jphysiol.1996.sp021694
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outward currents in rabbit pulmonary artery cells dissociated with a new technique1991 · 115 citations
  2. 2Voltage-Gated K <sup>+</sup> Currents Regulate Resting Membrane Potential and [Ca <sup>2+</sup> ] <sub>i</sub> in Pulmonary Arterial Myocytes1995 · 295 citations
  3. 3The min K channel underlies the cardiac potassium current IKs and mediates species-specific responses to protein kinase C.1993 · 118 citations
  4. 4Augmentation by intracellular ATP of the delayed rectifier current independently of the glibenclamide‐sensitive K‐current in rabbit arterial myocytes1994 · 21 citations
  5. 5Calcium channel currents recorded from isolated myocytes of rat basilar artery are stretch sensitive.1993 · 129 citations