Capecitabine can cause severe, reversible cardiotoxicity including ST-elevation and ventricular tachycardia, necessitating prompt evaluation of chest pain and early cardiac monitoring.
Supports vigilance for capecitabine cardiotoxicity in chest pain evaluation; case report leaves open incidence and risk factors.
We present a case of capecitabine-induced cardiac toxicity manifested by chest pain, ST-segment elevation and ventricular tachycardia. Symptoms and ECG alterations were completely reversible after withdrawal of the drug. Coronary angiography demonstrated the absence of epicardial coronary spasm. We suggest cardiac monitoring with ECG Holter and effort ECG during the first days of drug administration. Prompt evaluation of chest pain in this setting is of paramount importance.
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Farina et al. (2009) studied this question.
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