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August 1, 1993Circulation ResearchOpen Access

Effects of monophasic and biphasic shocks on action potentials during ventricular fibrillation in dogs.

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Why the study?

Do monophasic and biphasic shocks differentially affect action potential duration and refractory periods during ventricular fibrillation in dogs?

Population

10 open-chest dogs with electrically induced ventricular fibrillation

Comparison

5-millisecond monophasic and 2.5/2.5-millisecond… vs Preshock action potential duration and…

Design

Preclinical

Authors

XZXiaohong ZhouAstraZeneca (Italy)PWPatrick D. WolfPennsylvania State UniversityDRDennis L. RollinsHeart Rhythm Society

Discussion

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Implication

Urges caution extrapolating canine VF shock effects to humans; leaves open clinical relevance of waveform-specific repolarization.

Structured PICO

Do monophasic and biphasic shocks differentially affect action potential duration and refractory periods during ventricular fibrillation in dogs?

P
Population
10 open-chest dogs with electrically induced ventricular fibrillation
I
Intervention
5-millisecond monophasic and 2.5/2.5-millisecond biphasic shocks or 16-millisecond monophasic and 8/8-millisecond biphasic shocks (5 V/cm truncated exponential shocks)
C
Comparator
Preshock action potential duration and comparison between monophasic and biphasic waveforms
O
Outcome
Action potential duration at 50% repolarization (APD50) and refractory period during ventricular fibrillationsurrogate

Monophasic shocks cause greater prolongation of action potential duration and have shorter refractory periods compared to comparable biphasic shocks during ventricular fibrillation in dogs.

Cite This Study

Zhou et al. (1993) studied this question.

synapsesocial.com/papers/6a7e5158410afd830ac76be4https://doi.org/10.1161/01.res.73.2.325
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conduction disturbances caused by high current density electric fields.1990 · 156 citations
  2. 2Decreased defibrillator-induced dysfunction with biphasic rectangular waveforms1984 · 104 citations
  3. 3Intracellular recording of in situ ventricular cells during ventricular fibrillation1981 · 79 citations
  4. 4Improved defibrillator waveform safety factor with biphasic waveforms1983 · 93 citations
  5. 5Electrophysiological Effects of Monophasic and Biphasic Stimuli in Normal and Infarcted Dogs1990 · 49 citations